Some frames of interest from the story trailer worth mentioning. First off, we have a screenshot of Claire ducking before Leon shoots the zombie behind her. Notice the revolver in her hand. This means that the method Claire obtains her gun is different. This could also mean the gameplay starts before Leon and Claire meet, and that the intro is playable even before the truck crash.
Next we have the aforementioned elevator Claire and Sherry escape to, most likely from Mr. X before he is rudely eviscerated by Birkin. It appears that Birkin takes a drop with Claire somewhere later in the game, probably leading into the sewers.
Next we have a screenshot of the jail cells from Leon's point of view. It appears this scene is again, borrowing from 1.5 by having zombies locked in the cells that later get released in the following image.
Now we have a screenshot of Leon and Ada taking a stroll through the city streets and what appears to be a gun store to the left. Whether it's Kendo's or not, I can't quite make out. But it's nice to see the city actually looks like a city and that the streets aren't one lane thick like in RE3.
Finally, and by far most interesting are these two shots.
Judging by the proportions of the body and the size from the doorknob in the background, it is safe to say Resident Evil has it's first child zombie appearance. I'm actually quite interested to see how this scene plays out in the game, if child zombies will be an enemy, or just this one girl in a cutscene.